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Because CBD has a very low affinity for CNR1, the mode of interaction with Sevoflurane may be related to its uncontested and thoroughly reported calcium regulation in the mitochondria. The one patient which experienced this adverse event had a de novo nonsense mutation in the D4 location nucleic acid position of the SCN1A receptor. A nonsense mutation knocks out the rest of the C-terminus protein which contains the Calmodulin binding domain.
Nonsense mediated decay was not reported, but CBD did limit the seizures. Certain compounds found in some foods can influence cytochromes. Bergamottin in grapefruit juice can inhibit some cytochromes, leading to longer effective dosages of AEDs which are dependent on these same cytochromes.
This has been presented as a risk to Dravet children, but scientists voicing these concerns may not be aware of all of the papers in this space to put this risk into proper perspective. This is a major flaw in reasoning, as it assumes all cannabis is the same. Likewise, other cannabinoids and terpenes are frequently not measured in such studies making it difficult to correlate this risk to epilepsy patients using predominately CBD-rich cannabis.
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I keep seeing this question being asked. Its time to fully address it once and for all! Is cbd from hemp the same as cbd from cannabis? This question is flawed …. Because all hemp is cannabis, though not all cannabis is hemp! The United States government differentiated hemp from cannabis by definition in the federal farm bill of section to state that all cannabis with less than 0. Now, the subject can be broken down to even more analytics.
Not all hemp is created equal and furthermore not all oil is created equal. Most hemp throughout history has been grown for its seed because hempseed oil is high in omega-3's and other essential fatty acid's as well as protein and other vitamins and minerals.
So hempseed hempseed oil and hemp is a superfood packed w greatness. Also the other vast majority of hemp has been grown for it's pulpous fibre in order to make industrial hemp products like Rope, houses, etc. Hemp rope has been used on US Navy ships for decades.
These genetic cultivars grown for fibrous pulp generally lack and abundance of cannabinoids as well as desired Terpenes. I say desired because they're still terpenes there however they're not nearly as elite beneficial,desired as some of the more artisanal genetics offer.
What is an artisanal hemp strain? I grow these artisanal strains of cannabis with less than 0. I also grow higher thc content plants. Terpenes, aside from containing their own benefits of mood and function, are what helps the medicine cross our blood brain barrier. No terpenes, less feeling, less smell, worse taste, less effective. Even if I had the greatest strain, the extraction process is very important to determine resulting efficacy and so is how the material is taken care of once it has grown that is called the curing process.
The same 2 strains extracted in dif ways will produce dif results. Its like proudly promoting vegetarian fed chickens, chickens need protein bugs,worms just as much as cannabis needs terpenes. Liposomal means molecules are encased in a lipid shell for maximum bioavailability.
Cannabis as we know is fat soluble, so delivering cannabinoids and terpenes in a healthy fat helps our body uptake the beneficials without waste and deliver to necessary parts of our body.
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