Hyperalgesia is a condition where a person develops an increased sensitivity to pain. What may not hurt most people can cause significant pain in an individual with hyperalgesia. Another kind of hyperalgesia is opioid-induced hyperalgesia (OIH). Hyperalgesia is an abnormally increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can cause. Hyperalgesia is an enhanced pain response. It can result from either injury to part of the body or from use of opioid painkillers. When a person.
Mechanisms for these phenomena relate to neuroplastic changes in the peripheral and central nervous system that lead to sensitisation of pronociceptive pathways. Opioid induced hyperalgesia is not usually seen in the absence of observed tolerance to opioid analgesia.
While there are many proposed mechanisms for OIH, five mechanisms are probably the most the important involving: This might be qualitatively and anatomically distinct from pain related to disease progression or to breakthrough pain resulting from development of opioid tolerance.
Pain associated with hyperalgesia tends to be more diffuse than the pre-existing pain and less defined in quality. Management of opioid induced hyperalgesia requires opioid dose reduction or changing to an alternative opioid preparation.
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Gradual withdrawal of remifentanil infusion may prevent opioid-induced hyperalgesia. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https: By accessing the work you hereby accept the Terms.
Summary Remifentanil has unique pharmacologic properties as compared with other opioids, offering several clinical advantages. Remifentanil is the opioid with the highest reported incidence of OIH. Several drugs have been proposed in order to reduce hyperalgesia, but the evidence is still inconsistent and mostly arising from small single-center studies. More research is needed, possibly performing large-scale randomized trials with a standardized clinical approach for diagnosis and measurement of hyperalgesia.
Opioid Induced Hyperalgesia
Opioid-induced hyperalgesia (OIH) is defined as a state of nociceptive sensitization caused by exposure to opioids. The condition is characterized by a . Hyperalgesia and allodynia are frequent symptoms of disease and may be useful adaptations to protect vulnerable tissues. Enhanced sensitivity for pain may. Find out what hyperalgesia is and see how it's involved in fibromyalgia, chronic fatigue syndrome, and other sensitivity syndromes.