Pure and Organic CBD & and Hemp Products

Effective medicine provided by mother nature

  • Powerful relaxant

  • Strong painkiller

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  • Energy booster

Why CBD?

More and more renowned scientists worldwide publish their researches on the favorable impact of CBD on the human body. Not only does this natural compound deal with physical symptoms, but also it helps with emotional disorders. Distinctly positive results with no side effects make CBD products nothing but a phenomenal success.

This organic product helps cope with:

  • Tight muscles
  • Joint pain
  • Stress and anxiety
  • Depression
  • Sleep disorder

Range of Products

We have created a range of products so you can pick the most convenient ones depending on your needs and likes.

CBD Capsules Morning/Day/Night:

CBD Capsules

These capsules increase the energy level as you fight stress and sleep disorder. Only 1-2 capsules every day with your supplements will help you address fatigue and anxiety and improve your overall state of health.

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CBD Tincture

CBD Tincture

No more muscle tension, joints inflammation and backache with this easy-to-use dropper. Combined with coconut oil, CBD Tincture purifies the body and relieves pain. And the bottle is of such a convenient size that you can always take it with you.

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Pure CBD Freeze

Pure CBD Freeze

Even the most excruciating pain can be dealt with the help of this effective natural CBD-freeze. Once applied on the skin, this product will localize the pain without ever getting into the bloodstream.

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Pure CBD Lotion

Pure CBD Lotion

This lotion offers you multiple advantages. First, it moisturizes the skin to make elastic. And second, it takes care of the inflammation and pain. Coconut oil and Shia butter is extremely beneficial for the health and beauty of your skin.

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Blue Moon Hemp Tru Blu CBD Tincture – Peppermint Flavor

CBD Healing cannabinoid

deathz
18.08.2018

Content:

  • CBD Healing cannabinoid
  • Everything you need to know about CBD oil
  • What is CBD oil?
  • The cannabis-derived chemical is non-psychoactive, and – while federally illegal – has been hailed as a cure for disease. Cannabidiol (CBD) is an active ingredient in cannabis derived from the Now I am not surprised they take this natural healing substance and. In just a few years, cannabidiol (CBD) has become immensely in a large survey among medicinal cannabis users published in [7].

    CBD Healing cannabinoid

    Furthermore, it has been reported that signaling pathways are differentially regulated by cannabinoids in normal cells versus cancer cells. In malignancies, such as thyroid cancer, lymphoma, melanoma, pancreas and breast cancer, the levels of cannabinoid receptors are often higher in the tumor compared with normal cells of the same origin, resulting in increased sensitivity to cannabinoids in the malignancies [ 89 , — ]. Moreover, many animal studies have reported antiproliferative and pro-apoptotic effects of cannabinoids on tumor cells but not on normal tissue [ 89 , 91 ].

    Thus, the role of the cannabinoid system in cancer indicates that this system is involved in regulating many of the functions that are essential in cancer development.

    Allergic asthma is a complex inflammatory disorder characterized by airway hyper-responsiveness, elevated serum IgE, recruitment of eosinophils into the lung and mucus hypersecretion by goblet cells [ ].

    While most studies have shown that cannabinoids, such as THC, facilitate a Th1 to Th2 cytokine switch, as discussed previously, it is surprising that cannabinoids can also suppress allergic asthma triggered primarily by Th2 cytokines. Previous findings indicated that aerosolized THC was capable of causing significant bronchodilatation with minimal systemic side effects, but had a local irritating effect on the airways [ ].

    Further bronchodilator effects of cannabinoids administered orally or by aerosol to asthmatic patients have also been reported [ , ]. Similarly, endogenous cannabinoids have been shown to regulate airway responsiveness.

    It was reported that activation of CB1 receptors by locally released anandamide may participate in the control of bronchial contractility. However, the authors further suggested that the effects of AEA may depend on the state of the bronchial muscle. During capsaicin-evoked bronchospasm, AEA may reduce the muscle contraction, whereas AEA may cause bronchoconstriction in the absence of vagus nerve-constricting tone [ ]. Cannabidiol has been shown to be effective in protecting endothelial function and integrity in human coronary artery endothelial cells HCAECs.

    In addition, proliferation and migration was markedly increased in activated cell populations. The use of CB2 agonists JWH and HU inhibited all activated pathways in a dose-dependent manner, establishing a novel use for these cannabinoid compounds [ ]. EAU was strongly inhibited when the CB2 was engaged and the effects of CB2 engagement appeared to be mediated predominantly through downregulation of T-cell function with a less-marked effect on antigen presentation [ ].

    An impaired T-cell-proliferative response in leukocytes from JWHtreated mice was also accompanied by marked reductions in cytokine production. A study performed by Li et al.

    Similarly, CBD treatment has been shown to significantly inhibit and delay destructive insulitis and inflammatory Th1-associated cytokine production in nonobese diabetes-prone NOD female mice.

    A recent study indicated that treatment of 11—week-old female NOD mice, either in a latent diabetes stage after 14 weeks or with initial symptoms of diabetes appearing up to 14 weeks with CBD for 4 weeks, could lead to sustained inhibition of insulitis [ ].

    CBD treatment inhibited specific destruction of the islets and reduced the infiltrates by mononuclear cells into the islets, thus preventing diabetes.

    Furthermore, cannabinoids have also been demonstrated to possess additional beneficial effects in animal models of diabetes. It has been reported that rats treated with CBD for periods of 1—4 weeks experienced significant protection from diabetic retinopathy [ ]. Cannabinoids have also been shown to alleviate neuropathic pain associated with the disease. Mice injected with a cannabis receptor agonist experienced a reduction in diabetic-related tactile allodynia compared with nontreated controls [ ].

    Thus, cannabinoids can be considered useful for controlling T1D due to their anti-inflammatory properties. It is becoming increasingly clear that cannabinoid receptors and their endogenous ligands play a crucial role in the regulation of the immune system.

    Exogenous cannabinoids have been shown to suppress T-cell-mediated immune responses by primarily inducing apoptosis and suppressing inflammatory cytokines and chemokines. Such observations indicate that targeting cannabinoid receptor—ligand interactions may constitute a novel window of opportunity to treat inflammatory and autoimmune disorders. As CB2 receptors are primarily expressed on immune cells, targeting CB2 may result in selective immunomodulation without overt toxicity.

    The future challenges for the use of cannabinoids as anti-inflammatory drugs include synthesis of cannabinoid receptor agonists that are nonpsychoactive with anti-inflammatory activity and then identifying their mode of action. Although current studies suggest that cannabinoids are useful therapeutic agents in the treatment of various inflammatory disorders, further evaluation of the mechanisms that account for their anti-inflammatory properties is necessary.

    Such studies may involve the use of cannabinoid receptor-knockout mice and use of receptor-specific compounds. Whether endocannabinoids and cannabinoid receptors play a critical role during normal inflammatory response also requires further consideration. Moreover, cannabinoid receptor signaling and effect of cannabinoids on adhesion molecules, co-stimulatory molecules and chemokines require further study in order to increase our understanding of cannabinoids and their intricate effects on immune system disorders.

    Overall, cannabinoids have exhibited significant potential to be used as novel anti-inflammatory agents and specific targeting of CB2 receptors holds the promise of mediating immunosuppressive effects without exerting psychotropic side effects.

    The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.

    This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. For reprint orders, please contact moc.

    No writing assistance was utilized in the production of this manuscript. National Center for Biotechnology Information , U. Author manuscript; available in PMC Aug 1. Author information Copyright and License information Disclaimer. The publisher's final edited version of this article is available at Future Med Chem. See other articles in PMC that cite the published article. Abstract Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors.

    Table 1 Selected cannabinoid molecules. Open in a separate window. Apoptotic effects of cannabinoids on immune cell populations One major mechanism of immunosupression by cannabinoids is the induction of cell death or apoptosis in immune cell populations. Cannabinoid action on cytokines Cytokines are the signaling proteins synthesized and secreted by immune cells upon stimulation. Table 2 Effect of cannabinoids on cytokine and chemokine production.

    Cannabinoids and multiple sclerosis The three main cell types that are involved in demyelination of the nerve fibers and axons in the CNS include activated T-cells, microglia and astrocytes. Reactive oxygen species production by mitochondria. Future perspective It is becoming increasingly clear that cannabinoid receptors and their endogenous ligands play a crucial role in the regulation of the immune system. Executive summary Cannabinoids, the active components of Cannabis sativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 CB1 and CB2.

    The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties. Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. Cannabinoids have been tested in several experimental models of autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, colitis and hepatitis and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.

    Cannabinoids may also be beneficial in certain types of cancers that are triggered by chronic inflammation. In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis. Sometimes, response to self antigens can trigger severe tissue injury.

    Footnotes For reprint orders, please contact moc. CA Cancer J Clin. Pollmann W, Feneberg W. Current management of pain associated with multiple sclerosis. Cannabinoids for control of chemotherapy induced nausea and vomiting: Croxford JL, Yamamura T. Cannabinoids and the immune system: Cannabinoid receptors as therapeutic targets. Annu Rev Pharmacol Toxicol. Cannabinoid receptors are coupled to nitric oxide release in invertebrate immunocytes, microglia, and human monocytes.

    Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Biophys Res Commun. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Identification of intracellular carriers for the endocannabinoid anandamide.

    The biochemistry of apoptosis. J Pharmacol Exp Ther. Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection.

    A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells. Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes. CB2 cannabinoid receptor agonist, JWH, triggers apoptosis in immune cells: Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.

    Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis. Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL Possible involvement of the CB2 receptor in cell differentiation.

    Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin in endotoxemic mice. Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid. Inhibitory effect of synthetic cannabinoids on cytokine production in rheumatoid fibroblast-like synoviocytes.

    Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells. Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis. Progesterone up-regulates anandamide hydrolase in human lymphocytes: The challenge of multiple sclerosis: Cannabinoids and multiple sclerosis. CB2 cannabinoid receptors as an emerging target for demyelinating diseases: The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis.

    T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Aranami T, Yamamura T. Therapeutic action of cannabinoids in a murine model of multiple sclerosis. A cannabinoid agonist interferes with the progression of a chronic model of multiple sclerosis by downregulating adhesion molecules. Stimulation of cannabinoid receptor 2 CB2 suppresses microglial activation. A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL and IL in microglial cells.

    The CB 2 cannabinoid receptor controls myeloid progenitor trafficking: The endogenous cannabinoid system protects against colonic inflammation. Cannabinoids and the gastrointestinal tract. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. A comparative analysis of two models of colitis in rats. Antibodies to interleukin 12 abrogate established experimental colitis in mice.

    Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium. Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation.

    Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Prostaglandins Leukot Essent Fatty Acids. Vasodilator mRNA levels are increased in the livers of portal hypertensive NO-synthase 3-deficient mice. Maria January 1, I tried CBd oil and the rub I have fibromyalgia arthris and my joints are bad and I have not found any relief.

    Terry December 23, I was in a car accident and have had many back surgeries and nerves cut in my leg. As a result I have a lot of pain. I also have arthritis. Debra December 20, Sandra December 5, I am trying to recover from 2 ankle surgeries. I am in quite a bit of pain. What kind of oil do you recommend? Cynthia December 4, Great breakdown of the differences between these two cannabinoids, thanks for the good info!

    Alice October 18, I am looking for something for aches, pains and weight loss, what kind of oil do you recommend? WIll B November 7, Full spectrum has trace amounts of THC. Margie August 7, Leave a Reply Cancel reply Your email address will not be published.

    Send this to friend Your email Recipient email Send Cancel. Instead of moving, other families obtained CBD oil through the illegal distribution networks. If Epidiolex wins approval it would be the first time the agency approves a drug derived from the marijuana plant.

    Epidiolex was developed by the London-based GW Pharmaceuticals , which grows cannabis on tightly controlled farms in the UK.

    While parents treating their children with CBD had to proceed based on trial and error, like a folk medicine, they also had to wonder whether dispensary purchased CBD was professionally manufactured and contained what the package said it did. GW brought a scientific understanding and pharmaceutical grade manufacturing to this promising compound. The company is also studying cannabinoid-based drugs as a treatment for autism spectrum disorders, an aggressive brain tumor called glioblastoma, and schizophrenia.

    Other industries, not subject to the strict regulations governing pharmaceuticals are eager to develop their own CBD products, everything from joints and vape pens to skin creams and edibles which may or may not have valid medical use. Topics Cannabis High time:

    Everything you need to know about CBD oil

    Some patients believe CBD has the most medicinal benefit of all the cannabis compounds. But most of them do not realize that there are. The body of research on cannabidiol, CBD oil benefits, THC, and other . show that cannabis preparations have been used for wound healing in both animals. Hemp CBD oil might be different from cannabis CBD oil, but it's plants are used for a multitude of purposes, not just medicinal or recreational.

    What is CBD oil?



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